CLINICO-IMMUNOLOGICAL AND MICROBIOLOGICAL STUDY OF BRONCHIAL ASTHMA WITH SPECIAL REFERENCE TO ASPERGILLUS

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Author Details : J K Mishra, Usha Singh, Ragini Tilak, S K Meena, G Singh

Volume : 2, Issue : 3, Year : 2015

Article Page : 104-110

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Abstract

Background: Allergic bronchopulmonary aspergillosis (ABPA) is a hypersensitivity reaction to Aspergillus mycelia that colonize in the bronchi. The susceptibility of asthmatic patients to develop ABPA is not fully understood.
Aim: To evaluate the clinical, immunological, microbiological and radiological features of Aspergillus infection in patients with asthma.
Methodology: 50 Patients with Bronchial Asthma as cases and 20 age and sex matched non asthmatic individuals as controls were selected for study from OPD of Department of TB and Respiratory Diseases, University Hospital, Institute of Medical Sciences, Banaras Hindu University, Varanasi during the period of January 2013 to July 2014. Various clinical, immunological, microbiological and radiological features of aspergillus infection in patients were recorded. The observed data was analyzed and intergroup comparisons were done.
Result:  In patients of bronchial asthma with positive aspergillus the percentage of presence of breathlessness, cough, family history, allergic rhinitis, history of ATT intake, AEC, IgE, IgG, BAL and CECT Thorax lied between 62.5% to 100% and most of these showed statistically significant difference.
Conclusion The development of ABPA is probably the combination of many genetic susceptibility factors. Understanding of the genetic risks and immuno-pathogenesis of ABPA will lead to early diagnosis and improved treatment of ABPA.

Keywords:  Aspergillus, Aspergillosis, Bronchopulmonary Aspergillosis (ABPA), Bronchial Asthma

How to cite : Mishra J K, Singh U, Tilak R, Meena S K, Singh G, CLINICO-IMMUNOLOGICAL AND MICROBIOLOGICAL STUDY OF BRONCHIAL ASTHMA WITH SPECIAL REFERENCE TO ASPERGILLUS. J Community Health Manag 2015;2(3):104-110

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