GENETIC ANALYSIS OF PATIENTS WITH PRIMARY OPEN ANGLE GLAUCOMA (POAG) IN NORTH INDIAN POPULATION


Author Details : Abhishek Dixit, Diksha Prakash, Samir Kumar, Mousumi Mutsuddi, OPS Maurya, S P Singh, Abhishek Chand

Volume : 2, Issue : 4, Year : 2015

Article Page : 168-178


Suggest article by email

Get Permission

Abstract

Aim: To investigate the role of the methylenetetrahydrofolate reductase (MTHFR) 677C>T polymorphism in a large cohort of patients with POAG.
Methods: genetic analysis of 80 patients of POAG and 80 controls was done for MTHFR 677C>T polymorphism using PCR.
Results: The C677T genotype is found to be very significantly associated with POAG) as compared to the controls. There is a significant difference in the frequency of distribution of genotype. The homozygous mutant genotype (TT) is also 1.25% more in cases as compared to controls.
Conclusion: There is significant association of MTHFR 677C>T polymorphism with POAG.

Key words:
Glaucoma, Intraocular pressure, Primary open angle glaucoma

 

 


How to cite : Dixit A, Prakash D, Kumar S, Mutsuddi M, Maurya O, Singh S P, Chand A, GENETIC ANALYSIS OF PATIENTS WITH PRIMARY OPEN ANGLE GLAUCOMA (POAG) IN NORTH INDIAN POPULATION. J Community Health Manag 2015;2(4):168-178


This is an Open Access (OA) journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.







View Article

PDF File  


Copyright permission

Get article permission for commercial use

Downlaod

PDF File    






Article Access statistics

Viewed: 1265

PDF Downloaded: 461